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Managing Lab SOPs as a Living Knowledge Base

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Our protocols keep changing. How do we prevent chaos while still improving them?

Laboratory methods are not static documents. They evolve.

  • Incubation times are optimized
  • Reagents are replaced
  • Equipment changes
  • Troubleshooting knowledge accumulates
  • Students contribute improvements

Over time, a single SOP may exist in multiple slightly different versions across computers, emails, and printed folders.

This guide demonstrates how a laboratory can transform its SOP collection into a living knowledge base using Git.

Instead of treating protocols as isolated documents, we treat them as:

  • Versioned knowledge
  • Collaborative artefacts
  • Traceable scientific infrastructure

Git is not the goal.
It is the mechanism that enables structured SOP governance.

Scientific knowledge evolves.
Your protocol system should evolve with it.

Learning Objectives

After this guide, you will understand:

  • How to organize SOPs as Markdown files
  • How to manage them in a Git repository
  • How to track procedural evolution
  • How to coordinate multi-person editing
  • How to freeze protocol versions for publications
  • How to establish basic governance rules